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Article

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.

The Journal of biological chemistry - 29 Jun 2001

Glading A, Uberall F, Keyse S M, Lauffenburger D A, Wells A

Abstract excerpt

Localization of signaling is critical in directing cellular outcomes, especially in pleiotropic signaling pathways. The extracellular signal-regulated kinase (ERK)/microtubule-associated protein kinase, which promotes cell migration, proliferation, and differentiation is found in the nucleus and throughout the cytoplasm. Recently, it has been shown that nuclear translocation of ERK is required for transcriptional...

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Source

Identifiers

PMID: 11319218
DOI: 10.1074/jbc.M008847200

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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