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Article

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

The Journal of cell biology - 10 Mar 2008

Cortesio Christa L, Chan Keefe T, Perrin Benjamin J, Burton Nicholas O, Zhang Sheng, Zhang Zhong-Yin, Huttenlocher Anna

Abstract excerpt

Invasive cancer cells form dynamic adhesive structures associated with matrix degradation called invadopodia. Calpain 2 is a calcium-dependent intracellular protease that regulates adhesion turnover and disassembly through the targeting of specific substrates such as talin. Here, we describe a novel function for calpain 2 in the formation of invadopodia and in the invasive abilities of breast cancer cells through...

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Source

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Identifiers

PMID: 18332219
DOI: 10.1083/jcb.200708048
PMCID: PMC2265405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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