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Article

MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2008

Skarpen Ellen, Flinder Liv Ingrid, Rosseland Carola Maria, Orstavik Sigurd, Wierød Lene, Oksvold Morten Pedersen, Skålhegg Bjørn Steen, Huitfeldt Henrik Sverre

Abstract excerpt

In this study, we provide novel insight into the mechanism of how ERK2 can be sorted to different intracellular compartments and thereby mediate different responses. MEK1-activated ERK2 accumulated in the nucleus and induced proliferation. Conversely, MEK2-activated ERK2 was retained in the cytoplasm and allowed survival. Localization was a determinant for ERK2 functions since MEK1 switched from providing...

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PMID: 17928366
DOI: 10.1096/fj.07-8650com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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