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Article

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.

The EMBO journal - 1 Feb 1999

Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J

Abstract excerpt

Mitogen-activated protein kinase (MAPK) modules, composed of three protein kinases activated by successive phosphorylation, are involved in the signal transduction of a wide range of extracellular agents. In mammalian cells, mitogenic stimulation triggers the translocation of p42/p44MAPK from the cytoplasm to the nucleus, whereas the other protein kinases of the module remain cytosolic. Since MAPK has been shown...

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Identifiers

PMID: 9927426
DOI: 10.1093/emboj/18.3.664
PMCID: PMC1171159

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Source receipt: pubmed, retrieved 7 Sept 2026.

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