Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.

doi:10.1093/emboj/18.3.664

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Article

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.

The EMBO journal - 1 Feb 1999

Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J

Abstract excerpt

Mitogen-activated protein kinase (MAPK) modules, composed of three protein kinases activated by successive phosphorylation, are involved in the signal transduction of a wide range of extracellular agents. In mammalian cells, mitogenic stimulation triggers the translocation of p42/p44MAPK from the...

Topics

Animals
Biological Transport, Active
Calcium-Calmodulin-Dependent Protein Kinases
Cell Cycle
Cell Line
Cell Nucleus
Cricetinae
Cytoplasm
Dual Specificity Phosphatase 6
Gene Expression
Growth Substances
Humans
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 9927426
DOI: 10.1093/emboj/18.3.664
PMCID: PMC1171159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927426-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mitogen-Activated Protein Kinase 3

Mitogen-Activated Protein Kinases

Mutation

Phosphorylation