Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation.

Molecular and cellular biology - 1 Sept 2011

Plotnikov Alexander, Chuderland Dana, Karamansha Yael, Livnah Oded, Seger Rony

Abstract excerpt

The extracellular signal-regulated kinases (ERK) 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase [MAPK] family. Upon stimulation, these kinases translocate from the cytoplasm to the nucleus, where they induce physiological processes such as proliferation and differentiation. The mechanism of translocation of this kinase involves phosphorylation of two Ser residues within a nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Casein Kinase II
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetulus

Share to Glutathione Transferase

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Nuclear Localization Signals

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 21730285
DOI: 10.1128/MCB.05424-11
PMCID: PMC3165556

Genes

NTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation.PMID 21730285Read ↗

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.Semantic proximity Read ↗

Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.Semantic proximity Read ↗

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.Semantic proximity Read ↗

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking.Semantic proximity Read ↗

Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear TranslocationSemantic proximity Read ↗

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1Semantic proximity Read ↗

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Semantic proximity Read ↗

Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.Semantic proximity Read ↗

Identification and characterization of nuclear localization signals of CaMKP-N.Semantic proximity Read ↗

Mitogen-activated 3p kinase is active in the nucleus.Semantic proximity Read ↗

Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.Semantic proximity Read ↗

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.