Article
Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2006
Watson Lisa C, Moffatt-Blue Chantelle S, McDonald R Zachary, Kompfner Elizabeth, Ait-Azzouzene Djemel, Nemazee David, Theofilopoulos Argyrios N, Kono Dwight H, Feeney Ann J
Abstract excerpt
CDR3 regions containing two D segments, or containing the footprints of V(H) replacement events, have been reported in both mice and humans. However, the 12-23 bp rule for V(D)J recombination predicts that D-D rearrangements, which would occur between 2 recombination signal sequences (RSSs) with 12-bp spacers, should be extremely disfavored, and the cryptic RSS used for V(H) replacement is very inefficient. We...
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