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Article

Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments.

Neuroscience - 1 Jan 2001

Dowjat W K, Wisniewski H, Wisniewski T

Abstract excerpt

Mutations in presenilin-1 gene are responsible for the majority of early-onset familial Alzheimer's disease cases. The function of this protein and the mechanism underlying the pathogenicity of its mutations are still unclear. To elucidate the role of presenilin-1 in the Alzheimer's disease pathology, we tested two such mutations (P117L and M146L) for their effect in stably transfected mouse neuroblastoma cell...

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Identifiers

PMID: 11311782
DOI: 10.1016/s0306-4522(00)00550-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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