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Article

[Neurofibrillary tangles and early modification of the neuronal cytoskeleton in Alzheimer's disease and in experimental models].

Bulletin et memoires de l'Academie royale de medecine de Belgique - 1 Jan 1999

Brion J P

Abstract excerpt

Neurofibrillary tangles, a hallmark neuropathological lesion of Alzheimer's disease and of the other tauopathies, are composed of hyperphosphorylated tau proteins (a microtubule-associated protein) assembled in the form of abnormal filaments. Hyperphosphorylation of tau proteins appears to be an early phenomenom, preceding their aggregation into fibrillar structures. This hyperphosphorylation could result from...

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PMID: 10992876

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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