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Article

Interaction of presenilins with the filamin family of actin-binding proteins.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1998

Zhang W, Han S W, McKeel D W, Goate A, Wu J Y

Abstract excerpt

Mutations in presenilin genes PS1 and PS2 account for approximately 50% of early-onset familial Alzheimer's disease (FAD). The PS1 and PS2 genes encode highly homologous transmembrane proteins related to the Caenorhabditis elegans sel-12 and spe-4 gene products. A hydrophilic loop region facing t...

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PMID: 9437013
PMCID: PMC2042137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9437013-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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