Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.

Neuroscience letters - 28 May 1999

Dowjat W K, Wisniewski T, Efthimiopoulos S, Wisniewski H M

Abstract excerpt

Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines. The P117L mutation is associated with the earliest onset of AD reported so far (24 years), while the M146L is les...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Blotting, Western
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Growth Inhibitors

Share to Neurites

Share to Presenilin-1

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10400232
DOI: 10.1016/s0304-3940(99)00351-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10400232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.PMID 10400232Read ↗

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.Semantic proximity Read ↗

A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.Semantic proximity Read ↗

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.Semantic proximity Read ↗

The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells.Semantic proximity Read ↗

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.Semantic proximity Read ↗

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.Semantic proximity Read ↗

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells.Semantic proximity Read ↗

Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1.Semantic proximity Read ↗

Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments.Semantic proximity Read ↗

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.Semantic proximity Read ↗

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.Semantic proximity Read ↗

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.