Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

Neuroscience letters - 26 Dec 2003

Leroy K, Boutajangout A, Richardson J, Octave J N, Lovestone S, Anderton B H, Brion J P

Abstract excerpt

The expression of familial Alzheimer's disease mutants of presenilin-1 (PS1) proteins has been observed to induce cell death in cellular systems. To investigate how this phenomenon might be associated to alterations of the microtubule network, we have studied the effect of wild-type and mutant (C263R, P264L and delta9) PS1 proteins expression on the formation of microtubule-dependent processes outgrowth and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Cell Death
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Immunoblotting

Share to Indoles

Share to Presenilin-1

Share to tau Proteins

Source

Identifiers

PMID: 14665422
DOI: 10.1016/j.neulet.2003.09.051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.PMID 14665422Read ↗

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.Semantic proximity Read ↗

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells.Semantic proximity Read ↗

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.Semantic proximity Read ↗

Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments.Semantic proximity Read ↗

The tau mutation (val337met) disrupts cytoskeletal networks of microtubules.Semantic proximity Read ↗

Differential effects of human TAU isoforms: Somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAUSemantic proximity Read ↗

Abnormal microtubule packing in processes of SF9 cells expressing the FTDP-17 V337M tau mutation.Semantic proximity Read ↗

Effects of wild type tau and disease-linked tau mutations on microtubule organization and intracellular trafficking.Semantic proximity Read ↗

DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowthSemantic proximity Read ↗

[Biochemistry of presenilin 1].Semantic proximity Read ↗

The presenilin-1 familial Alzheimer's disease mutation P117L decreases neuronal differentiation of embryonic murine neural progenitor cells.Semantic proximity Read ↗

Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.