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Article

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells.

Journal of pharmacological sciences - 1 Nov 2006

Tsuchiya Daiju, Kitamura Yoshihisa, Takata Kazuyuki, Taniguchi Takashi, Uemura Kengo, Miki Hiroaki, Takenawa Tadaomi, Shimohama Shun

Abstract excerpt

Presenilin 1 (PS1) is a multifunctional protein, and its mutations are highly related to familial Alzheimer's disease (AD). In this study, we examined the effects of PS1 overexpression on neuronal morphology using SH-SY5Y cells. Overexpression of dominant-negative D385A PS1 induced morphological change and impairment of neurite formation, while those of wild-type and pathogenic P117L mutant PS1 did not change...

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PMID: 17099291
DOI: 10.1254/jphs.sc0060118

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