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Article

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2001

Ishihara T, Higuchi M, Zhang B, Yoshiyama Y, Hong M, Trojanowski J Q, Lee V M

Abstract excerpt

Previous studies have shown that transgenic (Tg) mice overexpressing human tau protein develop filamentous tau aggregates in the CNS. The most abundant tau aggregates are found in spinal cord and brainstem in which they colocalize with neurofilaments (NFs) as spheroids in axons. To elucidate the role of NF subunit proteins in tau aggregate formation and to test the hypothesis that NFs are pathological chaperones...

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Identifiers

PMID: 11487626
PMCID: PMC6763173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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