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Article

Presenilin is required for proper morphology and function of neurons in C. elegans.

Nature - 20 Jul 2000

Wittenburg N, Eimer S, Lakowski B, Röhrig S, Rudolph C, Baumeister R

Abstract excerpt

Mutations in the human presenilin genes cause the most frequent and aggressive forms of familial Alzheimer's disease (FAD). Here we show that in addition to its role in cell fate decisions in non-neuronal tissues, presenilin activity is required in terminally differentiated neurons in vivo. Mutations in the Caenorhabditis elegans presenilin genes sel-12 and hop-1 result in a defect in the temperature memory of...

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Identifiers

PMID: 10917532
DOI: 10.1038/35018575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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