Article
The monocyte/IgE connection: may polymorphisms in the CD14 gene teach us about IgE regulation?
International archives of allergy and immunology - 1 Jan 2000
Vercelli D, Baldini M, Martinez F
Abstract excerpt
BACKGROUND: Total IgE levels are known to be under genetic control. Linkage studies have indicated that one or more loci on chromosome 5q may control total IgE, as well as asthma and bronchial hyperresponsiveness to nonspecific stimuli. Our group has undertaken a systematic analysis of chromosome 5q, and has recently characterized five single nucleotide polymorphisms at position -1619, -1359, -1145, -809 and -159...
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