Article
Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy.
Allergy - 1 Oct 2003
Bucková D, Hollá L I, Schüller M, Znojil V, Vácha J
Abstract excerpt
BACKGROUND: Immunoglobulin E (IgE)-mediated allergy belongs to common chronic disorders resulting from an interaction between both genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31.1, a region that is linked to asthma and bronchial hyperresponsiveness. Recently, several polymorphisms in the promoter region of this...
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