The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.

doi:10.1038/s41598-018-20483-1

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Article

The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes.

Scientific reports - 7 Mar 2018

Nieto-Fontarigo J J, Salgado F J, San-José M E, Cruz M J, Casas-Fernández A, Gómez-Conde M J, Valdés-Cuadrado L, García-González M Á, Arias P, Nogueira M, González-Barcala F J

Abstract excerpt

LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma. Therefore, CD14 modulation could alter the TH2-differentiation and should be taken into account when studying asthma. To analyse the alteration in CD14 levels and its association with CD14 (-159 C/T) SNP (rs2569190) in Caucasian adults...

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PMID: 29515128
DOI: 10.1038/s41598-018-20483-1
PMCID: PMC5841440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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