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Article

The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma.

Allergy - 1 Jan 2011

Sackesen C, Birben E, Soyer O U, Sahiner U M, Yavuz T S, Civelek E, Karabulut E, Akdis M, Akdis C A, Kalayci O

Abstract excerpt

BACKGROUND: Even though the genotype at the promoter region of the CD14 molecule is known to affect the atopic phenotypes, the cellular and molecular basis of this association is largely unknown. OBJECTIVE: To investigate the effect of lipopolysaccharide (LPS) on IgE production and cytokine profi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

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Source

Identifiers

PMID: 20608916
DOI: 10.1111/j.1398-9995.2010.02428.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20608916-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma.PMID 20608916Read ↗

The effect of CD14-c159T genotypes on the cytokine response to endotoxin by peripheral blood mononuclear cells from asthmatic children.Semantic proximity Read ↗

The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma.Semantic proximity Read ↗

The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.Semantic proximity Read ↗

159C>T CD14 genotype--functional effects on innate immune responses in term neonates.Semantic proximity Read ↗

Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort.Semantic proximity Read ↗

Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation.Semantic proximity Read ↗

The effect of CD14 and TLR4 gene polymorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study.Semantic proximity Read ↗

A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.Semantic proximity Read ↗

A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children.Semantic proximity Read ↗

The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children.Semantic proximity Read ↗

The role of lipopolysaccharide in the development of atopy in humans.Semantic proximity Read ↗

Failure to find an association between CD14-159C/T polymorphism and asthma: a family-based association test and meta-analysis.Semantic proximity Read ↗

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