Article
The functional genomics of CD14 and its role in IgE responses: an integrated view.
The Journal of allergy and clinical immunology - 1 Jan 2002
Vercelli Donata
Abstract excerpt
Several studies in recent years have suggested that there is a strong genetic component in the pathogenesis of IgE-mediated diseases. Epidemiologic studies have identified a number of genes that carry single base changes (single nucleotide polymorphisms) associated with parameters of allergy. What remain to be established are the mechanisms whereby genetic variation results in dysregulation of IgE-mediated...
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