Article
Alkyl-lysophospholipid 1-O-octadecyl-2-O-methyl- glycerophosphocholine induces invasion through episialin-mediated neutralization of E-cadherin in human mammary MCF-7 cells in vitro.
International journal of cancer - 15 May 2001
Steelant W F, Goeman J L, Philippé J, Oomen L C, Hilkens J, Krzewinski-Recchi M A, Huet G, Van der Eycken J, Delannoy P, Bruyneel E A, Mareel M M
Abstract excerpt
1-O-octadecyl-2-O-methyl-glycerophosphocholine (ET-18-OMe) is an analogue of the naturally occurring 2-lysophosphatidylcholine belonging to the class of antitumor lipids. Previously, we demonstrated that ET-18-OMe modulates cell-cell adhesion of human breast cancer MCF-7 cells. In the present study, we tested the effect of ET-18-OMe on adhesion, invasion and localisation of episialin and E-cadherin in MCF-7/AZ...
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