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Article

Levels of Soluble E-Cadherin in Breast, Gastric, and Colorectal Cancers

1 Jan 2014

Abstract excerpt

Soluble E-cadherin is a 80 kDa protein fragment coming from the proteolytic cleavage of the extracellular domain of the full length epithelial cadherin, a molecule involved in cell adhesion/polarity and tissue morphogenesis. In comparison with normal epithelia, cancer cells show a decreased cadherin-mediated intercellular adhesion, and sE-cad levels normally increase in body fluids (blood and urine). This review...

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Identifiers

PMID: 25535613
DOI: 10.1155/2014/408047

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