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Article

Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin.

Cancer research - 15 Dec 2000

Sasaki C Y, Lin H, Morin P J, Longo D L

Abstract excerpt

E-cadherin has been demonstrated to induce growth suppression and decrease the invasiveness of cancer cells and thus has been proposed to be a tumor suppressor gene. The ability of E-cadherin to mediate cell-cell contact and contact inhibition presumably accounts for its antitumor effects, which are attributed to the extracellular domain of the protein. Here we report that blocking the ability of E-cadherin to...

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PMID: 11156412

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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