Article
Regulation of tumor phenotypes by caveolin-1 and sphingolipid-controlled membrane signaling complexes.
Biochimica et biophysica acta - 1 Mar 2008
Prinetti Alessandro, Prioni Simona, Loberto Nicoletta, Aureli Massimo, Chigorno Vanna, Sonnino Sandro
Abstract excerpt
Aberrant (glyco)sphingolipid expression deeply affects several properties of tumor cells that are involved in tumor progression and metastasis formation: cell adhesion (to the extracellular matrix or to the endothelium of blood vessels), motility, recognition and invasion of host tissues. In particular, (glyco)sphingolipids might contribute to the modulation of integrin-dependent interactions of tumor cells...
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