Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role for p120 catenin in E-cadherin function.

The Journal of cell biology - 11 Nov 2002

Ireton Renee C, Davis Michael A, van Hengel Jolanda, Mariner Deborah J, Barnes Kirk, Thoreson Molly A, Anastasiadis Panos Z, Matrisian Linsey, Bundy Linda M, Sealy Linda, Gilbert Barbara, van Roy Frans, Reynolds Albert B

Abstract excerpt

Indirect evidence suggests that p120-catenin (p120) can both positively and negatively affect cadherin adhesiveness. Here we show that the p120 gene is mutated in SW48 cells, and that the cadherin adhesion system is impaired as a direct consequence of p120 insufficiency. Restoring normal levels o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Delta Catenin
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catenins

Share to Cell Adhesion Molecules

Share to Cell Size

Share to Indicators and Reagents

Share to Luminescent Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 12427869
DOI: 10.1083/jcb.200205115
PMCID: PMC2173073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12427869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role for p120 catenin in E-cadherin function.PMID 12427869Read ↗

Functions of p120-catenin in physiology and diseasesSemantic proximity Read ↗

p120-catenin binding masks an endocytic signal conserved in classical cadherins.Semantic proximity Read ↗

α-Catenin contributes to the strength of E-cadherin-p120 interactions.Semantic proximity Read ↗

Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn).Semantic proximity Read ↗

p120-catenin in cancer – mechanisms, models and opportunities for interventionSemantic proximity Read ↗

The role of E-cadherin-catenin complex: more than an intercellular glue?Semantic proximity Read ↗

p120-catenin controls contractility along the vertical axis of epithelial lateral membranes.Semantic proximity Read ↗

N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin.Semantic proximity Read ↗

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.Semantic proximity Read ↗

p120-independent modulation of E-cadherin adhesion activity by the membrane-proximal region of the cytoplasmic domain.Semantic proximity Read ↗

p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions.Semantic proximity Read ↗

Altered expression of the catenin p120 in human cancer: implications for tumor progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.