Article
Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype.
Cancer research - 1 Sept 1994
Bracke M E, Charlier C, Bruyneel E A, Labit C, Mareel M M, Castronovo V
Abstract excerpt
Tamoxifen is an antiestrogen used in adjuvant therapy of breast carcinoma and could potentially prevent the development of mammary cancer. While it is widely clinically used, its exact mechanisms of action are not yet fully elucidated. MCF-7/6 cells are estrogen receptor-positive invasive human breast cancer cells with a functionally inactive cell surface E-cadherin. In this study, we report that tamoxifen, and...
Topics
- Breast Neoplasms
- Cadherins
- Calcium
- Cell Adhesion
- Female
- Humans
- Insulin-Like Growth Factor I
- Neoplasm Invasiveness
- Phenotype
- Tamoxifen
- Tumor Cells, Cultured