Article
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008
May Dalit, Gilon Dan, Djonov Valentin, Itin Ahuva, Lazarus Alon, Gordon Oren, Rosenberger Christian, Keshet Eli
Abstract excerpt
A key energy-saving adaptation to chronic hypoxia that enables cardiomyocytes to withstand severe ischemic insults is hibernation, i.e., a reversible arrest of contractile function. Whereas hibernating cardiomyocytes represent the critical reserve of dysfunctional cells that can be potentially rescued, a lack of a suitable animal model has hampered insights on this medically important condition. We developed a...
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