Article
Gestational stress induces the unfolded protein response, resulting in heart defects.
Development (Cambridge, England) - 15 Jul 2016
Shi Hongjun, O'Reilly Victoria C, Moreau Julie L M, Bewes Therese R, Yam Michelle X, Chapman Bogdan E, Grieve Stuart M, Stocker Roland, Graham Robert M, Chapman Gavin, Sparrow Duncan B, Dunwoodie Sally L
Abstract excerpt
Congenital heart disease (CHD) is an enigma. It is the most common human birth defect and yet, even with the application of modern genetic and genomic technologies, only a minority of cases can be explained genetically. This is because environmental stressors also cause CHD. Here we propose a plausible non-genetic mechanism for induction of CHD by environmental stressors. We show that exposure of mouse embryos to...
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