Article
Gene-environment interaction demonstrates the vulnerability of the embryonic heart.
Developmental biology - 1 Jul 2014
O'Reilly Victoria C, Lopes Floro Kylie, Shi Hongjun, Chapman Bogdan E, Preis Jost I, James Alexander C, Chapman Gavin, Harvey Richard P, Johnson Randall S, Grieve Stuart M, Sparrow Duncan B, Dunwoodie Sally L
Abstract excerpt
Mammalian embryos develop in a low oxygen environment. The transcription factor hypoxia inducible factor 1a (HIF1α) is a key element in the cellular response to hypoxia. Complete deletion of Hif1α from the mouse conceptus causes extensive placental, vascular and heart defects, resulting in embryonic lethality. However the precise role of Hif1α in each of these organ systems remains unknown. To further...
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