Article
The Drosophila insulin receptor is required for normal growth.
Endocrinology - 1 Mar 1996
Chen C, Jack J, Garofalo R S
Abstract excerpt
Drosophila contain an insulin receptor homologue, encoded by the inr gene located at position 93E4-5 on the third chromosome. The receptor protein is strikingly homologous to the human receptor, exhibiting the same alpha2beta2 subunit structure and containing a ligand- activated tyrosine kinase in its cytoplasmic domain. Chemical mutagenesis was used to induce mutations in the inr gene and six independent...
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