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Article

Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.

Genetics - 9 Feb 2021

Yamamoto Rochele, Palmer Michael, Koski Helen, Curtis-Joseph Noelle, Tatar Marc

Abstract excerpt

Mutations of the Drosophila melanogaster insulin/IGF signaling system slow aging, while also affecting growth and reproduction. To understand this pleiotropy, we produced an allelic series of single codon substitutions in the Drosophila insulin receptor, InR. We generated InR substitutions using homologous recombination and related each to emerging models of receptor tyrosine kinase structure and function. Three...

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Identifiers

PMID: 33724413
DOI: 10.1093/genetics/iyaa037
PMCID: PMC8045697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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