Article
An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2001
Snijders A, Elferink D G, Geluk A, van Der Zanden A L, Vos K, Schreuder G M, Breedveld F C, de Vries R R, Zanelli E H
Abstract excerpt
Predisposition to rheumatoid arthritis (RA) is thought to be associated with HLA-DR1, -DR4, and -DR10. However, many epidemiological observations are better explained by a model in which the DQ alleles that are linked to these DR alleles, i.e., DQ5, DQ7, and DQ8, predispose to RA, while certain DR alleles have a dominant protective effect. All protective DRB1 alleles, e.g., *0402, *1301, and *1302, encode a...
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