Article
HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis.
Human immunology - 1 Feb 1999
van der Horst-Bruinsma I E, Visser H, Hazes J M, Breedveld F C, Verduyn W, Schreuder G M, de Vries R R, Zanelli E
Abstract excerpt
We have recently proposed a new hypothesis to explain the association of Human Leukocyte Antigen (HLA) with rheumatoid arthritis (RA) predisposition. In this model, which challenges the Shared Epitope (SE) hypothesis, HLA-DQ predisposes while HLA-DR protects. In the present study, we have compared these two models in an Early Arthritis Clinic started in 1993 in the Department of Rheumatology at the Leiden...
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