Article
Several common HLA-DR types share largely overlapping peptide binding repertoires.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1998
Southwood S, Sidney J, Kondo A, del Guercio M F, Appella E, Hoffman S, Kubo R T, Chesnut R W, Grey H M, Sette A
Abstract excerpt
The peptide binding specificities of HLA-DRB1*0401, DRB1*0101, and DRB1*0701 have been analyzed by the use of large collections of synthetic peptides corresponding to naturally occurring sequences. The results demonstrated that nearly all peptides binding to these DR molecules bear a motif charac...
Topics
- Algorithms
- Alleles
- Amino Acid Sequence
- Binding Sites
- Cell Line, Transformed
- Databases, Factual
- Epitopes
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Molecular Sequence Data
- Peptides