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Article

Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism

9 Sept 2019

Abstract excerpt

Significance HLA genes confer the strongest genetic autoimmune disease risk. Specific HLA-DRB1 alleles predispose to rheumatoid arthritis (RA), while others encoding the sequence DERAA are RA-protective. Unexpectedly, having given birth to children with DERAA + HLA-DRB1 alleles prior to onset was found to increase RA risk in women. We show that microchimerism (Mc; allogeneic cell long-term legacy of pregnancy)...

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PMID: 31501349
DOI: 10.1073/pnas.1904779116

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