Article
Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations.
Arthritis and rheumatism - 1 May 2010
van der Woude Diane, Lie Benedicte A, Lundström Emeli, Balsa Alejandro, Feitsma Anouk L, Houwing-Duistermaat Jeanine J, Verduijn Willem, Nordang Gry B N, Alfredsson Lars, Klareskog Lars, Pascual-Salcedo Dora, Gonzalez-Gay Miguel A, Lopez-Nevot Miguel A, Valero Fernando, Roep Bart O, Huizinga Tom W J, Kvien Tore K, Martín Javier, Padyukov Leonid, de Vries René R P, Toes René E M
Abstract excerpt
OBJECTIVE: The protective effect of HLA-DRB1 alleles on the development of rheumatoid arthritis (RA) is poorly understood. The aim of this study was to perform a meta-analysis of 4 European populations to investigate which HLA-DRB1 alleles are associated with protection in anti-citrullinated protein antibody (ACPA)-positive RA and ACPA-negative RA. METHODS: Data for >2,800 patients and >3,000 control subjects for...
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