Article
Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition.
The Journal of clinical investigation - 1 Apr 1990
Weyand C M, Goronzy J J
Abstract excerpt
The susceptibility to develop seropositive rheumatoid arthritis (RA) has been linked to specific genomic polymorphisms within the HLA complex. Two different haplotypes have been associated with the disease, HLA-DR1 and HLA-DR4. To investigate the link between such phenotypic disease associations and potential immune mechanisms we used alloreactive and antigen-specific human T cell clones. Here we describe a panel...
Topics
- Alleles
- Antigens, Bacterial
- Arthritis, Rheumatoid
- Cross Reactions
- Epitopes
- HLA-DR Antigens
- Herpesvirus 4, Human
- Humans
- T-Lymphocytes