Article
Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone.
Human immunology - 1 Nov 2001
Vos K, Visser H, Schreuder G M, de Vries R R, Zwinderman A H, Breedveld F C, Hazes J M, Zanelli E H
Abstract excerpt
Conflicting data have been published on the value of the shared epitope (SE) hypothesis in predicting disease outcome in rheumatoid arthritis (RA). Recently we have proposed an alternative hypothesis, referred to as the RA protection (RAP) model. In this model, the HLA-DQ loci carry predisposition while HLA-DRB1 alleles encoding the motif DERAA provide protection against severe RA. In the present study, we have...
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