Article
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.
Cell - 23 Mar 2001
Howell C Y, Bestor T H, Ding F, Latham K E, Mertineit C, Trasler J M, Chaillet J R
Abstract excerpt
Maintenance of genomic methylation patterns in mammalian somatic cells depends on DNA methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but express a variant of this protein called Dnmt1o. We eliminated Dnmt1o by deletion of the oocyte-specific promoter and first exon from the Dnmt1 locus. Homozygous animals were normal, but most heterozygous fetuses of homozygous females died...
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