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Article

Dnmt3L and the establishment of maternal genomic imprints.

Science (New York, N.Y.) - 21 Dec 2001

Bourc'his D, Xu G L, Lin C S, Bollman B, Bestor T H

Abstract excerpt

Complementary sets of genes are epigenetically silenced in male and female gametes in a process termed genomic imprinting. The Dnmt3L gene is expressed during gametogenesis at stages where genomic imprints are established. Targeted disruption of Dnmt3L caused azoospermia in homozygous males, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11719692
DOI: 10.1126/science.1065848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11719692-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Dnmt3L and the establishment of maternal genomic imprints.PMID 11719692Read ↗

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Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Semantic proximity Read ↗

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.Semantic proximity Read ↗

Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.Semantic proximity Read ↗

Loss of the maternal imprint in Dnmt3L mice leads to a differentiation defect in the extraembryonic tissueSemantic proximity Read ↗

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3aSemantic proximity Read ↗

Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo.Semantic proximity Read ↗

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