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Article

Dnmt3L and the establishment of maternal genomic imprints.

Science (New York, N.Y.) - 21 Dec 2001

Bourc'his D, Xu G L, Lin C S, Bollman B, Bestor T H

Abstract excerpt

Complementary sets of genes are epigenetically silenced in male and female gametes in a process termed genomic imprinting. The Dnmt3L gene is expressed during gametogenesis at stages where genomic imprints are established. Targeted disruption of Dnmt3L caused azoospermia in homozygous males, and heterozygous progeny of homozygous females died before midgestation. Bisulfite genomic sequencing of DNA from oocytes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11719692
DOI: 10.1126/science.1065848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dnmt3L and the establishment of maternal genomic imprints.PMID 11719692Read ↗

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in miceSemantic proximity Read ↗

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Stochastic imprinting in the progeny of Dnmt3L−/− femalesSemantic proximity Read ↗

Origins of extreme sexual dimorphism in genomic imprinting.Semantic proximity Read ↗

Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.Semantic proximity Read ↗

Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Semantic proximity Read ↗

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.Semantic proximity Read ↗

Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.Semantic proximity Read ↗

Loss of the maternal imprint in Dnmt3L mice leads to a differentiation defect in the extraembryonic tissueSemantic proximity Read ↗

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3aSemantic proximity Read ↗

Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo.Semantic proximity Read ↗

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