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Article

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.

Nature - 24 Jun 2004

Kaneda Masahiro, Okano Masaki, Hata Kenichiro, Sado Takashi, Tsujimoto Naomi, Li En, Sasaki Hiroyuki

Abstract excerpt

Imprinted genes are epigenetically marked during gametogenesis so that they are exclusively expressed from either the paternal or the maternal allele in offspring. Imprinting prevents parthenogenesis in mammals and is often disrupted in congenital malformation syndromes, tumours and cloned animal...

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Identifiers

PMID: 15215868
DOI: 10.1038/nature02633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15215868-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.PMID 15215868Read ↗

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in miceSemantic proximity Read ↗

Dnmt3L and the establishment of maternal genomic imprints.Semantic proximity Read ↗

Stochastic imprinting in the progeny of Dnmt3L−/− femalesSemantic proximity Read ↗

Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.Semantic proximity Read ↗

Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3BSemantic proximity Read ↗

Origins of extreme sexual dimorphism in genomic imprinting.Semantic proximity Read ↗

Loss of the maternal imprint in Dnmt3L mice leads to a differentiation defect in the extraembryonic tissueSemantic proximity Read ↗

Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.Semantic proximity Read ↗

Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Semantic proximity Read ↗

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.Semantic proximity Read ↗

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline.Semantic proximity Read ↗

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in FemalesSemantic proximity Read ↗

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