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Article

Profound phenotypic variation among mice deficient in the maintenance of genomic imprints.

Human reproduction (Oxford, England) - 1 Apr 2008

Toppings Marc, Castro Carlos, Mills Parker H, Reinhart Bonnie, Schatten Gerald, Ahrens Eric T, Chaillet J Richard, Trasler Jacquetta M

Abstract excerpt

BACKGROUND: An alteration in the mechanism that maintains the monoallelic, imprinted expression of genes can result in their biallelic expression and lead to disruptions in fetal development. Here, we examined the consequences of a loss of maintenance methylation at one specific stage of preimplantation, induced by a deficiency of the oocyte-derived Dnmt1o protein and known to produce biallelic expression of...

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Share to DNA (Cytosine-5-)-Methyltransferase 1
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Source

Identifiers

PMID: 18276606
DOI: 10.1093/humrep/den009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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