Article
Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1.
Mechanisms of development - 1 Apr 2001
Naruse-Nakajima C, Asano M, Iwakura Y
Abstract excerpt
Eph receptors have been implicated in cell-to-cell interaction during embryogenesis. We generated EphA2 mutant mice using a gene trap method. Homozygous mutant mice developed short and kinky tails. In situ hybridization using a Brachyury probe found the notochord to be abnormally bifurcated at the caudal end between 11.5 and 12.5 days post coitum. EphA2 was expressed at the tip of the tail notochord, while one of...
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