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Article

Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.

Molecular and cellular biology - 1 May 2008

Sawada Atsushi, Kiyonari Hiroshi, Ukita Kanako, Nishioka Noriyuki, Imuta Yu, Sasaki Hiroshi

Abstract excerpt

Four members of the TEAD/TEF family of transcription factors are expressed widely in mouse embryos and adult tissues. Although in vitro studies have suggested various roles for TEAD proteins, their in vivo functions remain poorly understood. Here we examined the role of Tead genes by generating mouse mutants for Tead1 and Tead2. Tead2(-/-) mice appeared normal, but Tead1(-/-); Tead2(-/-) embryos died at embryonic...

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Source

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Identifiers

PMID: 18332127
DOI: 10.1128/MCB.01759-07
PMCID: PMC2423158

Genes

TEF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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