Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite.

doi:10.1016/0925-4773(93)90067-8

Back to search

Article

Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite.

Mechanisms of development - 1 Dec 1993

Dietrich S, Schubert F R, Gruss P

Abstract excerpt

We have characterised the patterning capacity of the notochord on the somite using the murine Pax-1 gene as a ventral, and Pax-3 as a dorsal molecular marker. As model systems we chose the four mouse notochord mutants Brachyury curtailed (Tc), Danforth's short tail (Sd), Pintail (Pt) and truncate...

Topics

Animals
Cell Differentiation
Female
Gene Expression
Genetic Markers
Heterozygote
Homozygote
Male
Mesoderm
Mice
Mice, Inbred Strains
Mutation
Notochord
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.