Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.

Developmental biology - 15 Oct 2015

Lewis Ace E, Hwa Jennifer, Wang Rong, Soriano Philippe, Bush Jeffrey O

Abstract excerpt

Ephrin-B2, a member of the Eph/ephrin family of cell signaling molecules, has been implicated in the guidance of cranial and trunk neural crest cells (NCC) and development of the branchial arches(BA), but detailed examination in mice has been hindered by embryonic lethality of Efnb2 null loss of function due to a requirement in angiogenic remodeling. To elucidate the developmental roles for Efnb2, we generated a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Cell Movement
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Fluorescent Antibody Technique

Share to Histological Techniques

Share to In Situ Hybridization

Share to Neural Crest

Source

Open in PubMed Open full text

Identifiers

PMID: 26385750
DOI: 10.1016/j.ydbio.2015.08.021
PMCID: PMC4639416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.PMID 26385750Read ↗

Ephrin-B1 forward and reverse signaling are required during mouse development.Semantic proximity Read ↗

Generation of transgenic mice overexpressing EfnB2 in endothelial cells.Semantic proximity Read ↗

Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.Semantic proximity Read ↗

Comparative analysis of embryonic gene expression defines potential interaction sites for Xenopus EphB4 receptors with ephrin-B ligands.Semantic proximity Read ↗

mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish.Semantic proximity Read ↗

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.Semantic proximity Read ↗

Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryoSemantic proximity Read ↗

fused-somites-like mutants exhibit defects in trunk vessel patterning.Semantic proximity Read ↗

Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism.Semantic proximity Read ↗

Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

Cell-autonomous and nonautonomous actions of endothelin-A receptor signaling in craniofacial and cardiovascular development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.