Article
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.
Genes & development - 15 Jul 2004
Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim
Abstract excerpt
The floating head (flh) gene in zebrafish encodes a homeodomain protein, which is essential for notochord formation along the entire body axis. flh orthologs, termed Not genes, have been isolated from chick and Xenopus, but no mammalian ortholog has yet been identified. Truncate (tc) is an autosomal recessive mutation in mouse that specifically disrupts the development of the caudal notochord. Here, we...
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