Article
The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.
Cell reports - 18 May 2021
Shan Chun-Min, Kim Jin-Kwang, Wang Jiyong, Bao Kehan, Sun Yadong, Chen Huijie, Yue Jia-Xing, Stirpe Alessandro, Zhang Zhiguo, Lu Chao, Schalch Thomas, Liti Gianni, Nagy Peter L, Tong Liang, Qiao Feng, Jia Songtao
Abstract excerpt
Oncogenic histone lysine-to-methionine mutations block the methylation of their corresponding lysine residues on wild-type histones. One attractive model is that these mutations sequester histone methyltransferases, but genome-wide studies show that mutant histones and histone methyltransferases often do not colocalize. Using chromatin immunoprecipitation sequencing (ChIP-seq), here, we show that, in fission...
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