Article
No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
Neuroscience letters - 5 Mar 1999
Wavrant-DeVrièze F, Rudrasingham V, Lambert J C, Chakraverty S, Kehoe P, Crook R, Amouyel P, Wu W, Holmans P, Rice F, Pérez-Tur J, Frigard B, Morris J C, Carty S, Cottel D, Tunstall N, Lovestone S, Petersen R C, Chartier-Harlin M C, Goate A, Owen M J, Williams J, Hardy J
Abstract excerpt
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.