Article
Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients.
Neuroscience letters - 17 Nov 2000
Zill P, Bürger K, Behrens S, Hampel H, Padberg F, Boetsch T, Möller H J, Ackenheil M, Bondy B
Abstract excerpt
Recent reports have suggested that genetic polymorphisms in the alpha-2 macroglobulin (A2M) gene are associated with an increased risk for Alzheimer's disease. In the present study we tested two polymorphisms in the alpha-2 macroglobulin gene, a 5 bp deletion at the 5' splice site of exon 18 and a G/A point mutation (V1000I) in exon 24, in a sample of 118 healthy, non demented controls and 238 consecutively...
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