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Article

The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation.

Clinical immunology (Orlando, Fla.) - 1 Jul 2001

Monson N L, Foster S J, Brezinschek H P, Brezinschek R I, Dörner T, Lipsky P E

Abstract excerpt

To determine whether CD40 ligation influences the molecular and selective mechanisms that govern the development of the human Ig light chain repertoire, analysis of the Vkappa and Vlambda repertoires of CD19+ B cells obtained from a patient with X-linked hyper IgM syndrome (XHIM) and a nonfunctional CD154 was carried out. The nonproductive Vkappa and Vlambda repertoires were largely comparable to that of the...

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Share to CD40 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Share to Hypergammaglobulinemia

Share to Immunoglobulin Joining Region

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Source

Identifiers

PMID: 11414747
DOI: 10.1006/clim.2001.5049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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